The Highways Agency has begun resurfacing work to a two-mile stretch of the A64 at the Golden Hill junction at Malton.
The four-week project, which began on Monday, includes resurfacing, the renewal of road markings and studs and will affect both the east and westbound lanes between High Hutton and Golden Hill.
Highways chiefs say that in order to minimise disruption to road users, the work will be carried out in the evening and overnight between 8pm and 6am.
Work will be undertaken using a convoy system of traffic control with a temporary speed limit of 40mph in place, dropping to 10mph while the convoy system is operating.
There may also be a need to close the Barneygate Lane junction during the work. A clearly-signed diversion will operate via Low Hutton Lane into Huttons Ambo when this is required.
The work is programmed to finish on June 13.